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Trial Acronym REST
Clinical Area Critical Care
Trial Title A pragmatic randomised controlled trial to determine whether Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) and lower tidal volume mechanical ventilation in patients with hypoxaemic respiratory failure improves 90 day mortality
Trial Status Analysis and Reporting
Trial Registration



  • Recruitment
    Recruitment Target 540
    Date Open to Recruitment May 2016
    Recruitment 412
    Date Closed to Recruitment February 2020
  • Trial Design

    Randomised, allocation concealed, controlled, open, pragmatic clinical and cost effectiveness trial.

    Study Aim

    To deliver a multi-centre clinical trial to determine whether VV-ECCO2R and lower tidal volume mechanical ventilation improves outcomes and is cost-effective, in comparison with standard care in patients who are mechanically ventilated for acute hypoxaemic respiratory failure.

  • Chief Investigator
    Chief Investigator Prof Danny McAuley, Queen’s University Belfast

  • Sponsor and Funder
    Sponsor Belfast Health and Social Care Trust
    Funder National Institute for Health and Care Research

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