The NICTU has a wide-ranging portfolio including expertise in Phase 2 and Phase 3 multi-centre clinical trials of investigational medicinal products (CTIMPs).  The NICTU has a specific interest in the development of Phase 2 studies where these are likely to lead to larger Phase 3 studies.  We also manage non IMP multi-centre trials.

AcronymProtocol TitleStatus
MARCHMucoactives in Acute Respiratory failure: Carbocisteine and Hypertonic saline.Open to Recruitment
REALISTRepair of Acute Respiratory Distress Syndrome by Stromal Cell AdministrationOpen to Recruitment
CLEARA 2x2 factorial randomised open label trial to determine the clinical and cost- effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in bronchiectasisOpen to Recruitment
PHINDClinical Evaluation of a Point of Care (POC) assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
Open to Recruitment
CHAMP-UKLow-dose atropine eye drops to reduce progression of myopia in children: a multi-centre placebo controlled randomised trial in the United Kingdom (CHAMP UK)Open to Recruitment
A-STOPAntifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients.Open to recruitment
A UK cohort of a Phase III study (CHALLENGE: the Colon Health and Lifelong Exercise Change study) of the impact of a physical activity programme on disease-free survival in patients with high risk Stage II or Stage III colon cancer: A Randomised Controlled trial. Open to recruitment
RESTProtective ventilation with veno-venous lung assist in respiratory failureAnalysis and Reporting
EASI-SWITCHEarly switch to oral antibiotic therapy in patients with low risk neutropenic sepsis.Analysis and Reporting
STARPredicting poor hand functional outcome in Rheumatoid Arthritis – a comparison of high resolution ultrasound examination and occupational therapy clinical hand assessment.Analysis and Reporting
POPSPrevention and Treatment of Steroid-Induced Osteopaenia in Children And Adolescents With Rheumatic Diseases (On Behalf of BSPAR).Analysis and Reporting
DIAMONDSDiabetic Macular Oedema and Diode Subthreshold Micropulse Laser (DIAMONDS): A pragmatic, multicentre, allocation concealed, prospective, randomised, non-inferiority double-masked trialAnalysis and Reporting
TRAC-24A single centre randomised controlled trial to assess the effect of the addition of twenty-four hours of oral tranexamic acid post-operatively to a single intra-operative intravenous dose of tranexamic acid on calculated blood loss following primary hip and knee replacement.
Analysis and Reporting
TEST-ITPoint Of Care Testing For Sepsis: A Diagnostic Accuracy Study
Analysis and Reporting
EMERALDEffectiveness of Multimodal imaging for the Evaluation of Retinal oedema And new vesseLs in Diabetic retinopathy
Analysis and Reporting
Walk with MeA feasibility study and pilot RCT of a peer-led walking programme to increase physical activity in inactive older adults: “Walk With Me Study”
Analysis and Reporting
EViSCOEpstein-Barr Virus Suppression in Chronic Obstructive Pulmonary DiseaseAnalysis and Reporting
MANAGEA large, international, placebo-controlled, trial to assess the impact of dabigatran (a direct thrombin inhibitor) and omeprazole (a proton-pump inhibitor) in patients suffering a myocardial infarction after noncardiac surgery.Closed
HARP-2Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction.Closed
KAREK eratinocyte growth factor in A cute lung injury to RE duce pulmonary dysfunction – a randomised placebo controlled trial (KARE).Closed
MoDUSHydroxymethylglutaryl-CoA reductase inhibition with simvastatin in mechanically ventilated patients at high risk of delirium.Closed
REVIVEEffectiveness of a programme of exercise on physical function in survivors of critical illness following discharge from the Intensive Care Unit (ICU): a randomised controlled trial.Closed
NIC-PIPA randomised controlled trial to measure the effects and costs of a dental caries prevention regime for young children attending primary care dental services.Closed
Vitamin D_CRC
Part A

Effects of Vit-D treatment on growth control biomarkers in human primary colorectal tumours (CRT).Closed
S PatrickSkin bacteria as a source of surgical infections: molecular epidemiology and prevention of wound contamination.Closed
STAMPPAdaptation of SHAHRP (Schools Alcohol Harm Reduction Programme) and TATI (Talking to Children About Tough Issues) Alcohol Misuse Prevention Programme (STAMPP): a school based cluster randomised controlled trial.Closed
VAP Rapid-2A randomised controlled trial of a biomarker based diagnosis of VAP to improve antibiotic stewardship.Closed
AFFECTA randomised controlled trial of calcium channel blockade with amlodipine for the treatment of subcortical ischaemic vascular dementiaClosed
PACKSComparing patient reported outcomes and costs in stage 5 chronic kidney disease managed with and without dialysis and the quality of life of their carers.Closed
CAPPCardiac CT for the Assessment of Chest Pain and Plaque.Closed
INRA randomised controlled pilot study to examine the cost effective analysis of guided patient self-management in conjunction with U-Tell INR for warfarin therapy.Closed
IRP StudyTreatment of Subacromial Shoulder Pain by Individual or Group Physiotherapy following Corticosteroid Injection.Closed
REACHAn evaluation of a multifaceted intervention to reduce antimicrobial prescribing in care home residents [REducing Antimicrobials in Care Homes (REACH)]: a non-randomised pilot study and process evaluation.Closed
ARA290-DMOA phase II Clinical Trial on the use of ARA 290 for the treatment of diabetic macular oedema
SANDWICHSedation AND Weaning In ChildrenClosed
MIRROREfficacy of the Telescopic Mirror Implant for Age-related Macular Degeneration: The MIRROR Trial (acronym MIRROR). A Multicentre Randomised Controlled Clinical TrialClosed
SAAFTHE SAAF STUDY: evaluation of the Safeguarding Children Assessment and Analysis Framework (SAAF), compared with management as usual, for improving outcomes for children and young people who have experienced, or are at risk of, maltreatment: study protocol for a randomised controlled trialClosed
STAR-ASPIRINASpirin as a Treatment for ARDS (STAR): a phase 2 randomised control trial.
JACK Feasibility StudyA multi-site cluster randomised trial of an interactive film-based intervention to reduce teenage pregnancy and promote positive sexual health
PREVENTION HARP-2"Prevention Of Post-operative Complications By Using HMG-CoA
Reductase Inhibitor In Patients Undergoing Oesophagectomy – A
multicentre, randomised, double blind, placebo controlled trial"