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Trial Acronym CHALLENGE-UK
Clinical Area Cancer
Trial Title A UK cohort of a Phase III study (CHALLENGE: the Colon Health and Lifelong Exercise Change study) of the impact of a physical activity programme on disease-free survival in patients with high risk Stage II or Stage III colon cancer: A Randomised Controlled trial
Trial Status Follow Up
Trial Registration

  • Recruitment
    Recruitment Target 160
    Date Open to Recruitment March 2018
    Recruitment 30
    Date Closed to Recruitment June 2022
  • Trial Design
    Trial Design A multi-national, multi-centre, randomised phase III interventional study.
    Study Aim To make a significant contribution to the main CHALLENGE Trial (to determine if a structured PA intervention can improve survival in patients with high risk Stage II/Stage III colon cancer), to ensure results are generalisable to the UK population and to determine feasibility and cost-effectiveness of delivering, and adherence to, a PA intervention in the UK.
    Objective 1: Three year disease-free survival.
    “Objective 2: Secondary objectives are to assess:
    • The feasibility of delivering the PA intervention in colon cancer survivors in the UK.
    • Objective fitness and compliance with the PA programme.
    • The acceptability of the PA programme to patients, families and health care professionals in a UK setting.
    • Health and Social Service Use and associated costs
    • Impact of colon cancer on work and activities”
  • Chief Investigator
    Chief Investigator Dr Victoria Coyle, Queen’s University Belfast

  • Sponsor & Funder
    Sponsor Queen’s University Belfast
    Funder Cancer Research UK (Population Research Committee)

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