| Trial Acronym | ACE |
| Trial Title | Study of Technologies for the Diagnosis of Angle Closure glaucoma (ACE) |
| Clinical Area | Ophthalmology |
| Trial Status | Open to Recruitment |
| Trial Registration | https://doi.org/10.1186/ISRCTN15115867 |
-
Recruitment
Recruitment Target 600 Date Open to Recruitment April 2023 Recruitment 609 as of July 2024 Date Closed to Recruitment Ongoing -
Trial Design
Trial Design This study will be a prospective, cross-sectional, multi-centre, diagnostic study of people referred to hospital eye services with suspected angle closure. Study Aim
Primary aim: To evaluate the diagnostic performance of two non-contact tests compared to gonioscopy (reference standard) by an expert consultant ophthalmologist.
Anterior segment optical coherence tomography (AS-OCT), will be interpreted by optometrists and photographers/imaging technicians and ophthalmologists.
Limbal anterior chamber depth (LACD), will be interpreted by optometrists.
Secondary aims:
a) To explore alternative thresholds for determining test positivity;
b) To evaluate the diagnostic performance of combinations of the tests;
c) To evaluate the cost-effectiveness of adopting individual tests or a combination of tests in a triage assessment, compared with the current practice of gonioscopy by an ophthalmologist at hospital eye services.
-
Chief Investigator
Chief Investigator Professor Augusto Azuara-Blanco, Queen’s University Belfast -
Sponsor & Funder
Sponsor Queen’s University Belfast Funder National Institute for Health and Care Research Health Technology Assessment (HTA) Programme
https://www.fundingawards.nihr.ac.uk/award/NIHR134593