PHIND Trial

Trial Acronym PHIND
Clinical Area Critical Care Unit
Description Clinical Evaluation of a Point of Care (POC) assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
Status Open to recruitment
RECRUITMENT
Target Recruitment 480
No. of Sites Minimum 22
TRIAL DESIGN
Trial Design A multi-centre, prospective, observational study
Study Aim The purpose of this project is to prospectively define hyper- and hypo-inflammatory phenotypes in patients with ARDS and determine clinical outcomes associated with each phenotype.
Objective 1: Assess the clinical outcomes in patients with ARDS according to their prospectively defined inflammatory phenotype determined using a POC assay.
Objective 2: (i) Assess the agreement of the phenotype allocation using a POC assay and the clinical study dataset
(ii) Assess the stability of phenotype allocation over time
(iii) Feasibility of delivering a POC assay in the NHS intensive care setting
CHIEF INVESTIGATOR (CI)
Chief Investigator Professor Danny McAuley
SPONSOR(s) & FUNDER(s)
Sponsor Queen’s University Belfast
Funder
Innovate UK