PHIND Trial

Trial Acronym	PHIND
Clinical Area	Critical Care Unit
Description	Clinical Evaluation of a Point of Care (POC) assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
Status	Open to recruitment

RECRUITMENT

Target Recruitment	480
No. of Sites	Minimum 22

TRIAL DESIGN

Trial Design

A multi-centre, prospective, observational study

Study Aim

The purpose of this project is to prospectively define hyper- and hypo-inflammatory phenotypes in patients with ARDS and determine clinical outcomes associated with each phenotype. Objective 1: Assess the clinical outcomes in patients with ARDS according to their prospectively defined inflammatory phenotype determined using a POC assay. Objective 2: (i) Assess the agreement of the phenotype allocation using a POC assay and the clinical study dataset (ii) Assess the stability of phenotype allocation over time (iii) Feasibility of delivering a POC assay in the NHS intensive care setting

CHIEF INVESTIGATOR (CI)

Chief Investigator

Professor Danny McAuley

SPONSOR(s) & FUNDER(s)

Sponsor	Queen’s University Belfast
Funder	Innovate UK