Trial Acronym | CHALLENGE-UK |
Clinical Area | Cancer |
Description | A UK cohort of a Phase III study (CHALLENGE: the Colon Health and Lifelong Exercise Change study) of the impact of a physical activity programme on disease-free survival in patients with high risk Stage II or Stage III colon cancer: A Randomised Controlled trial |
Status | Open for recruitment |
Recruitment Duration | 24 months |
Date Opened to Recruitment | 9th March 2018 |
Target Recruitment | 160 CHALLENGE-UK (962 being recruited to the global CHALLENGE study). |
Recruitment to date | Currently we have 34 patients registered and 30 patients randomised to the study. |
Date Closed to Recruitment | N/A |
No. of Sites | 4 |
Trial Design | A multi-national, multi-centre, randomised phase III interventional study. |
Study Aim | To make a significant contribution to the main CHALLENGE Trial (to determine if a structured PA intervention can improve survival in patients with high risk Stage II/Stage III colon cancer), to ensure results are generalisable to the UK population and to determine feasibility and cost-effectiveness of delivering, and adherence to, a PA intervention in the UK. |
Objective 1: Three year disease-free survival. | |
“Objective 2: Secondary objectives are to assess: • The feasibility of delivering the PA intervention in colon cancer survivors in the UK. • Objective fitness and compliance with the PA programme. • The acceptability of the PA programme to patients, families and health care professionals in a UK setting. • Health and Social Service Use and associated costs • Impact of colon cancer on work and activities” |
Chief Investigator | Dr Victoria Coyle |
Sponsors | Queen’s University Belfast |
Funder | Cancer Research UK (Population Research Committee) |