|Description||A UK cohort of a Phase III study (CHALLENGE: the Colon Health and Lifelong Exercise Change study) of the impact of a physical activity programme on disease-free survival in patients with high risk Stage II or Stage III colon cancer: A Randomised Controlled trial|
|Status||Open for recruitment|
|Recruitment Duration||24 months|
|Date Opened to Recruitment||9th March 2018|
|Target Recruitment||160 CHALLENGE-UK (962 being recruited to the global CHALLENGE study).|
|Recruitment to date||Currently we have 33 patients registered and 29 patients randomised to the study.|
|Date Closed to Recruitment||N/A|
|No. of Sites||4|
|Trial Design||A multi-national, multi-centre, randomised phase III interventional study.|
|Study Aim||To make a significant contribution to the main CHALLENGE Trial (to determine if a structured PA intervention can improve survival in patients with high risk Stage II/Stage III colon cancer), to ensure results are generalisable to the UK population and to determine feasibility and cost-effectiveness of delivering, and adherence to, a PA intervention in the UK.|
|Objective 1: Three year disease-free survival.|
|“Objective 2: Secondary objectives are to assess:
• The feasibility of delivering the PA intervention in colon cancer survivors in the UK.
• Objective fitness and compliance with the PA programme.
• The acceptability of the PA programme to patients, families and health care professionals in a UK setting.
• Health and Social Service Use and associated costs
• Impact of colon cancer on work and activities”
|Chief Investigator||Dr Victoria Coyle|
|Sponsors||Queen’s University Belfast|
|Funder||Cancer Research UK (Population Research Committee)|