| Trial Acronym | CHALLENGE-UK |
| Clinical Area | Cancer |
| Trial Title | A UK cohort of a Phase III study (CHALLENGE: the Colon Health and Lifelong Exercise Change study) of the impact of a physical activity programme on disease-free survival in patients with high risk Stage II or Stage III colon cancer: A Randomised Controlled trial |
| Trial Status | Follow Up |
| Trial Registration | https://www.clinicaltrials.gov/study/NCT00819208?term=NCT00819208&rank=1 |
-
Recruitment
Recruitment Target 160 Date Open to Recruitment March 2018 Recruitment 30 Date Closed to Recruitment June 2022 -
Trial Design
Trial Design A multi-national, multi-centre, randomised phase III interventional study. Study Aim To make a significant contribution to the main CHALLENGE Trial (to determine if a structured PA intervention can improve survival in patients with high risk Stage II/Stage III colon cancer), to ensure results are generalisable to the UK population and to determine feasibility and cost-effectiveness of delivering, and adherence to, a PA intervention in the UK. Objective 1: Three year disease-free survival. “Objective 2: Secondary objectives are to assess:
• The feasibility of delivering the PA intervention in colon cancer survivors in the UK.
• Objective fitness and compliance with the PA programme.
• The acceptability of the PA programme to patients, families and health care professionals in a UK setting.
• Health and Social Service Use and associated costs
• Impact of colon cancer on work and activities” -
Chief Investigator
Chief Investigator Dr Victoria Coyle, Queen’s University Belfast -
Sponsor & Funder
Sponsor Queen’s University Belfast Funder Cancer Research UK (Population Research Committee)