Trial Acronym | SANDWICH |
Clinical Area | Paediatric Critical Care |
Description | Sedation AND Weaning In CHildren |
Status | Analysis & Reporting |
Date Opened to Recruitment | February 2018 – October 2019 |
Target Recruitment | 9520 |
Recruitment to date | over 10,400 as of 14/10/2019 |
Date Closed to Recruitment | 14/10/2019 |
No. of Sites | 17 |
Trial Design | Prospective, cluster-randomised stepped wedge (SW) multi-centre clinical and cost-effectiveness trial with an internal pilot and a process evaluation. |
Study Aim | The aim of this study is to determine if a protocol-based intervention for the management of children in intensive care units can reduce the duration of invasive mechanical ventilation (IMV). The study involves co-ordinated care and greater nursing involvement in the sedation and ventilator weaning of children. It will also assess cost effectiveness compared with usual care.
Alongside the trial a process evaluation will be conducted using the principles of the Medical Research Council (MRC). |
Chief Investigator | Professor Bronagh Blackwood |
Sponsors | Queen’s University Belfast |
Funder | NIHR Health Technology Assessment Programme (HTA) |