| Trial Acronym | SANDWICH |
| Clinical Area | Paediatric Critical Care |
| Description | Sedation AND Weaning In CHildren |
| Status | Analysis & Reporting |
| Date Opened to Recruitment | February 2018 – October 2019 |
| Target Recruitment | 9520 |
| Recruitment to date | over 10,400 as of 14/10/2019 |
| Date Closed to Recruitment | 14/10/2019 |
| No. of Sites | 17 |
| Trial Design | Prospective, cluster-randomised stepped wedge (SW) multi-centre clinical and cost-effectiveness trial with an internal pilot and a process evaluation. |
| Study Aim | The aim of this study is to determine if a protocol-based intervention for the management of children in intensive care units can reduce the duration of invasive mechanical ventilation (IMV). The study involves co-ordinated care and greater nursing involvement in the sedation and ventilator weaning of children. It will also assess cost effectiveness compared with usual care.
Alongside the trial a process evaluation will be conducted using the principles of the Medical Research Council (MRC). |
| Chief Investigator | Professor Bronagh Blackwood |
| Sponsors | Queen’s University Belfast |
| Funder | NIHR Health Technology Assessment Programme (HTA) |